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The purpose of SIK1 in tumorigenesis. SIK1 can be a tumor suppressor gene, which plays a significant regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also promote c